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Corrine Kliment, MD, PhD

Research Interests

Dr. Kliment is a physician-scientist trained in Pulmonary and Critical Care medicine. The focus of her academic research program is to identify how mitochondrial function regulators cell fate and lung repair and regeneration in aging and lung disease. Recent studies have shown a unique role for adenine nucleotide translocases (ANTs, canonical mitochondrial ADP/ATP transporters) in the lung epithelium and inflammatory cells in chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). The lab has a specific interest in age-related pathways including cellular senescence and ferroptosis with a goal to identify new therapeutic avenues for intervention and disease assessment in chronic lung disease pathogenesis. The Kliment lab has utilizes mouse and human models including primary cell culture, 3D alveolar organoids and precision cut lung slices (PCLS) that can be utilized for therapeutic analysis. 

More information can be found at Dr. Kliment's lab website, linked here.

 

Selected Publications

  1. Kliment, CR^, Nguyen JMK, Kaltreider MJ, Lu Y, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN. Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function. J Cell Sci. 2021 Feb 25;134(4):jcs257162. doi: 10.1242/jcs.257162. PMID: 33526710; PMCID: PMC7929926. ^Corresponding
  2. Sui J*, Boatz JC*, Shi J, Hu Q, Li X, Zhang Y, Königshoff M, Kliment CR. Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2023 Nov;69(5):556-569. doi: 10.1165/rcmb.2022-0315OC. PMID: 37487137. *Co-first authors.
  3. Ware SA*, Kliment CR*, Giordano L, Redding KM, Rumsey WL, Bates S, Zhang Y, Sciurba FC, Nouraie SM, Kaufman BA. Cell-free DNA levels associate with COPD exacerbations and mortality. Respir Res. 2024 Jan 18;25(1):42. doi: 10.1186/s12931-023-02658-1. PMID: 38238743; PMCID: PMC10797855. *Co-first author
  4. Hu Y, Hu Q, Ansari M, Riemondy K, Pineda R, Sembrat J, Leme AS, Ngo K, Morgenthaler O, Ha K, Gao B, Janssen WJ, Basil MC, Kliment CR, Morrisey E, Lehmann M, Evans CM, Schiller HB, Königshoff M. Airway derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD. Eur Respir J. 2024 Aug 15:2302071. doi: 10.1183/13993003.02071-2023. Epub ahead of print. PMID: 39147413.
  5. Sui J, Xiao H, Mbaekwe U, Ting N, Murday K, Hu Q, Gregory AD, Kapellos TS, Yildirim A, Königshoff M, Zhang Y, Sciurba FC, Das J, Kliment CR.  Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD. JCI Insight, 2024 Oct 1:e180239. doi: 10.1172/jci.insight.180239. PMID: 39352744.
  6. Sui J, Johnson, A, Kapellos, T, Shiva, S, Kliment, CR. ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in COPD. Am J Respir Cell Mol Biol. Nov 2025. doi: 10.1165/rcmb.2024-0469OC. PMID: 40439531.
  7. Jha, R, Shi, J, Sedgwick, ME, Corcoran, T, Kliment, CR. Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates with Aging-associated Airway Remodeling. Aging Cell. 2025 (Accepted).