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Catherine K. Gestrich, DO

Assistant Professor of Pathology, Divisions of Pediatric and Molecular Genomic Pathology, Director of Pediatric Molecular Pathology and Genomics

Dr. Gestrich is a member of the Divisions of Pediatric and Molecular Genomic Pathology.

Clinical Expertise

Pediatric soft tissue neoplasms, molecular genomic pathology, vascular anomalies, pediatric melanocytic lesions

Certifications

The American Board of Pathology – Anatomic & Clinical Pathology
The American Board of Pathology – Molecular Genetic Pathology

The American Board of Pathology – Pediatric Pathology

Education & Training
DO - West Virginia School of Osteopathic Medicine (2017)
Residency in Anatomic & Clinical Pathology - Case Western Reserve University (2021)
Pediatric Pathology Fellowship - Boston Children’s Hospital/Harvard Medical School (2022)
Molecular Genetic Pathology Fellowship - University of Pittsburgh Medical Center (2023)
Research Interests

Molecular aspects of pediatric solid tumors, including brain tumors

Representative Publications

Molina LM, Pan Y, Wang Q, Salgado CM, Reyes-Múgica M, Aarabi M, Daghsni M, Skaugen JM, Gestrich CK. Integrating next-generation sequencing into the routine neuroblastoma workflow identifies actionable genomic alterations and reduces low-yield karyotype testing. Virchows Arch. 2026 Mar 17. doi: 10.1007/s00428-026-04483-5. PMID: 41840189.

Bedell M, Skaugen JM, Nikiforov Y, Reyes-Múgica M, Salgado CM, Simons JP, Wang Q, Gestrich CK. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in the adolescent and young adult population: A pediatric center experience. Hum Pathol. 2025 Nov;165:105951. doi: 10.1016/j.humpath.2025.105951. PMID: 41052728.

Gestrich CK, Kreiger P, Surrey L, Besmer S, Lopez-Terrada D, Church AJ; Society for Pediatric Pathology (SPP) Practice Committee. The implementation of molecular tumor profiling in the practice of pediatric cancer pathology: The pathologists' experience. Pediatr Blood Cancer. 2025 Jan;72(1):e31370. doi: 10.1002/pbc.31370. PMID: 39387390.

Gestrich CK, Al-Ibraheemi A. Pearls and Updates on Pediatric Tyrosine Kinase-Altered Tumors. Surg Pathol Clin. 2025 Jun;18(2):313-325. doi: 10.1016/j.path.2024.11.008. Epub 2024 Dec 3. PMID: 40412829.

Gestrich CK, Vivero MP, Konczyk DJ, Goss JA, Labow BI, Pearson GD, Cottrell CE, Mathew MT, Prasad V, Kozakewich HP, Fletcher CDM, Greene AK, Al-Ibraheemi A. Papillary Hemangioma Harbors Somatic GNA11 and GNAQ mutations. Am J Surg Pathol. 2023 Sep 26. doi: 10.1097/PAS.0000000000002127. PMID: 37750536.

Gestrich C, Davis JL, Biederman L, John I, Alaggio R, Giovannoni I, Arnold MA, Shenoy A, Tchakarov A, Al-Ibraheemi A. ALK-rearranged Epithelioid Mesenchymal Neoplasm: Expanding the Spectrum of Tyrosine Kinase Altered Mesenchymal Tumors. Mod Pathol. 2023 Sep 17:100334. doi: 10.1016/j.modpat.2023.100334. PMID: 37726067.

Gestrich C, Grieco K, Lidov HG, Baird LC, Fehnel KP, Yeo KK, Meredith DM, Alexandrescu S. H3K27-altered diffuse midline gliomas with MAPK pathway alterations: Prognostic and therapeutic implications. J Neuropathol Exp Neurol. 2023 Dec 22;83(1):30-35. doi: 10.1093/jnen/nlad103. PMID: 38037182.