Dr. Faccioli is the Director of the Organ Processing Hub and leads the Genetic Engineering and iPSC Platform at the Division of Experimental Pathology. She is expert in the isolation of primary human cells and tissues from explanted diseased organs, including liver, lung, kidney, and heart. Her work supports a wide range of translational research efforts aimed at understanding end stage human disease.
As the manager of the Human Liver Tissue & Hepatocytes Research Resource (HLTHRR), Dr. Faccioli provides access to high-quality, well-characterized non-parenchymal subpopulations, isolated from normal donor livers, which are distributed to investigators nationwide.
Dr. Faccioli’s research focuses on patient-specific liver disease modeling, using human cells to reconstruct the complex liver microenvironment in vitro. Her work aims to elucidate the cellular and molecular mechanisms driving chronic liver diseases. By developing physiologically relevant models, she enables the screening of potential therapeutics and supports the advancement of personalized treatment strategies.
- Faccioli LA, Sun Y, Animasahun O, Motomura T, Liu Z, Kurihara T, Hu Z, Yang B, Cetin Z, Baratta AM, Shankaran A, Nenwani M, Altay LN, Huang L, Meurs N, Franks J, Stolz D, Gavlock DC, Miedel MT, Ostrowska A, Florentino RM, Fox IJ, Nagrath D, Soto-Gutierrez A. Human induced pluripotent stem cell based hepatic-modeling of lipid metabolism associated TM6SF2 E167K variant. Hepatology. 2024 Aug 27. doi: 10.1097/HEP.0000000000001065. Epub ahead of print. PMID: 39190693.
- Hu Z, Kurihara T, Sun Y, Cetin Z, Florentino RM, Faccioli LAP, Liu Z, Yang B, Ostrowska A, Soto-Gutierrez A, Delgado ER. A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide. Front. Gastroenterol. Sec. Gastroenterology and Cancer, Volume 3 - 2024 | doi: 10.3389/fgstr.2024.1427820
- Ortiz K, Cetin Z, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Ostrowska A, Soto-Gutierrez A, Faccioli LAP. Human Hepatocellular response in Cholestatic Liver Diseases. Organogenesis. 2023 Dec 31;19(1):2247576. doi: 10.1080/15476278.2023.2247576. PMID: 37598346; PMCID: PMC10444014.
- Faccioli LAP#, Kocas-Kilicarslan ZN#, Diaz-Aragon R, Motomura T, Amirneni S, Malizio
- MR, Coard MC, Frau C, Haep N, Florentino RM, Ostrowska A. Human Hepatocytes Isolated from Explanted Livers: A Powerful Tool to Understand End-stage Liver Disease and Drug Screening. Organogenesis. 2021 Oct 2;17(3-4):117-125. doi: 10.1080/15476278.2021.1992216. PMID: 35114888; PMCID: PMC9208801. # Authors share first authorship
View all Dr. Faccioli`s publications on PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Lanuza+A+P+Faccioli