Dr. Florentino investigates the genetic and molecular basis of metabolic and cholestatic liver diseases, with a focus on translating discoveries into therapeutic advances. His research integrates patient-derived induced pluripotent stem cells (iPSCs), gene editing, and organ modeling to explore disease mechanisms and identify clinically relevant targets.
His work centers on conditions such as Progressive Familial Intrahepatic Cholestasis (PFIC), Primary Sclerosing Cholangitis (PSC), Primary Biliary Cholangitis (PBC), inherited liver disorders, and other cholestatic diseases. By combining patient-specific transcriptomic data, metabolic signatures, and genetic profiling with precision engineering tools, Dr. Florentino aims to dissect complex metabolic phenotypes and uncover novel pathways for intervention. Dr. Florentino is developing a comprehensive platform for molecular screening and therapeutic discovery, designed not only to improve treatments for cholestatic and metabolic liver diseases but also to serve as a blueprint for addressing broader hepatic conditions, advancing personalized medicine and improving outcomes for patients affected by these diseases.
View Dr. Florentino’s publications on PubMed