Assistant Professor of Radiology, Co-director of In vivo imaging facilities (Hillman Cancer Center)
Office Location:
Hillman Cancer Center G.17.b
5117 Centre Ave, Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-623-7239
Email: nedrowj@upmc.edu
Research Interest:
My research focus is on the development of novel radiopharmaceuticals for molecular imaging and targeted radiotherapy therapy. My graduate studies focused on the development of PET and SPECT imaging agents targeted to the prostate specific membrane antigen (PSMA). My post-doctoral work continued the development of PSMA-targeted PET agents for imaging as well as for targeted β-emitting radiotherapy. In addition, I also evaluated agents that I modified for PET imaging agents for breast and neuroendocrine cancers as well as melanoma. My lab works to develop and evaluate targeted radiotherapies by modifying antibodies and small molecules for a variety of cancers, particularly liver cancers, colorectal and gliomas.
Selected Publications:
Du Y, Cortez A, Josefsson A, Zarisfi M, Krimins R, Liapi E, Nedrow JR. Preliminary evaluation of alpha-emitting radioembolization in animal models of hepatocellular carcinoma. PLoS One. 2022;17(1):e0261982. doi: 10.1371/journal.pone.0261982. eCollection 2022. PubMed PMID: 35061763; PubMed Central PMCID: PMC8782514.
Cortez A, Josefsson A, McCarty G, Shtekler AE, Rao A, Austin Z, Nedrow JR. Evaluation of [225Ac]Ac-DOTA-anti-VLA-4 for targeted alpha therapy of metastatic melanoma. Nucl Med Biol. 2020 Sep-Oct;88-89:62-72. doi: 10.1016/j.nucmedbio.2020.07.006. Epub 2020 Jul 28. PubMed PMID: 32799049.
Nedrow JR, Latoche JD, Day KE, Modi J, Ganguly T, Zeng D, Kurland BF, Berkman CE, Anderson CJ. Targeting PSMA with a Cu-64 Labeled Phosphoramidate Inhibitor for PET/CT Imaging of Variant PSMA-Expressing Xenografts in Mouse Models of Prostate Cancer. Mol Imaging Biol. 2016 Jun;18(3):402-10. doi: 10.1007/s11307-015-0908-7. PubMed PMID: 26552656.
Complete list of publications –
https://www.ncbi.nlm.nih.gov/myncbi/18y4r69_fRB5p/bibliography/public/