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Kiyoko Oshima, MD, Ph.D.

Professor of Pathology, Division of Liver and Transplant Pathology

Dr. Kiyoko Oshima is a member of the Division of Liver and Transplant Pathology at the University of Pittsburgh Medical Center. She has practiced in academic medicine for more than twenty years and has developed extensive clinical expertise in hepatobiliary and transplant pathology.

Clinical Expertise

Dr. Oshima’s clinical expertise is in non-neoplastic and neoplastic hepatobiliary pathology and transplant pathology. She previously served as the Director of Clinical Hepatic Pathology at Johns Hopkins University School of Medicine, where she oversaw diagnostic quality, service operations, and clinical practice standards in liver pathology.

Education & Training Leadership

Dr. Oshima is committed to medical education and has served in multiple leadership roles, including Co-Director of Residency Training and Director of the Gastrointestinal/Liver Pathology Fellowship at several academic institutions.

Research Summary

Dr. Oshima’s research focuses on the morphologic and molecular characterization of hepatobiliary diseases and transplant pathology. Her ongoing projects include:

  1. 2D and 3D morphologic and molecular analysis of cholangiocarcinoma
     
  2. 2D and 3D morphologic analysis of hepatocytes regeneration in acute and chronic liver failure
     
  3. Antibody mediated and chronic rejection in liver transplantation

Honors

  • Faculty of the Year, Saint Louis University, 2009
  • Faculty Teacher of the Year, Medical College of Wisconsin, 2014

Memberships

  • Hans Popper Hepatopathology Society
  • United States and Canadian Academy of Pathology
  • American Society of Transplantation

Board Certifications

  • Anatomic Pathology, American Board of Pathology, 2001
  • Clinical Pathology, American Board of Pathology, 2001
Education & Training
UCLA Medical Center, Surgical Pathology Fellowship, 2002
University of Chicago, Blood Banking/Transfusion Medicine Fellowship, 2001
University of Illinois, Metropolitan hospitals, Residency, Anatomic and Clinical Pathology, 2000
Jikei University School of Medicine, Graduate School, PhD, 1991
Jikei University School of Medicine, Residency, Surgery, 1988
Jikei University School of Medicine, Medical Education, MD, 1983
Representative Publications

Eskandari F, Rowan DJ, Hari P, Kapke J, Schneidewend R, E Hagen C, Oshima K. Liver biopsy findings in patients with hematopoietic cell transplantation. Hum Pathol. 2017 Aug; 66:136-143

Pant M, Oshima K. Cholesteryl Ester Storage Disease: An underdiagnosed cause of cirrhosis in adults. Ann Diagn Pathol. 2017 Dec; 31:66-70

Yoshizawa T, Hong SM, Jung D, Noe M, Keimen A, Wu P, Wirtz D, Hruban R, Wood L, Oshima K. Three-dimensional analysis of extrahepatic cholangiocarcinoma and tumor budding. J Pathol. 2020 Aug; 251(4):400-410

Lee JW, Zhang Y, Yoshizawa T, Argani P, Wood LD, Oshima K. Cancerization of ducts in hilar   cholangiocarcinoma. Virchows Arch. 2022 Aug: 481 (2): 1-10.

Yoshizawa T, Lee JW, Hong SM, Jung D, Noë M, Zbijewski W, Kiemen A, Wu PH, Wirtz D, Hruban RH, Wood LD, Oshima K. Three-dimensional analysis of ductular reactions and their correlation with liver regeneration and fibrosis. Virchows Arch. 2024 May;484(5):753-763. 

Toomer K, Gurakar A, Oshima K. Antibody-medicated Rejection in Post-Liver Transplant Clinical Care: Are we were yet for timely diagnosis and Treatment? J liver Transplantation. 2024 Nov (16): 100236