Dr. Moore's research interests involve examining viruses that cause human cancer. Together with Dr. Yuan Chang, who is also a Distinguished and American Cancer Society Professor of Pathology, he discovered two of the seven viruses causing human cancers (Kaposi sarcoma herpesvirus and Merkel cell polyomavirus). Their laboratory examines the basic biology of these viruses and seeks to develop new approaches to vaccinate against human viruses.
View Dr. Moore’s publications (https://www.tumorvirology.pitt.edu/our-publications) on his laboratory website (https://www.tumorvirology.pitt.edu/).
Peng W-Y, Abere B, Shi H, Toland S, Smithgall TE, Moore PS, Chang Y. Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCg1 signaling through Src-family kinases. Proc Natl Acad Sci USA. 2023 Dec 19;120(51):e2316467120. doi: 10.1073/pnas.2316467120.
Wan L, Toland S, Robinson-McCarthy LR, Lee N, Schaich MA, Hengel SR, Li X, Bernstein KA, Van Houten B, Chang Y, Moore PS. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci USA. 2023 July 17; 120 (30) e2308010120. doi: 10.1073/pnas.2308010120.
Sun R, Guo S, Shuda Y, Chakka AB, Rigatti LH, Zhao G, Ali MAE, Park CY, Chandran U, Yu J, Bakkenist CJ, Shuda M , Moore PS, Chang Y. Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice. PLOS ONE. 2023 May 5;18(5): e0282722. doi: 10.1371/
Cao S, Jurczak MJ, Shuda Y, Sun R, Shuda M, Chang Y, Moore PS. Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice. PLOS ONE. 2023 Mar 10;18(3): e0282914. doi: 10.1371/journal.pone.0282914.
Meng W, Guo S, Cao S, Shuda M, Robinson-McCarthy LR, McCarthy KR, Shuda Y, Paniz-Mondolfi AE, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Li P, Zhang H, Perlman S, Guo H, Gao SJ, Chang Y, Moore PS. Development and Characterization of a New Monoclonal Antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2023 Jan; 95(1): e28246. doi: 10.1002/jmv.28246.