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Tim D. Oury, MD, PhD

Professor of Pathology, Division of Molecular & Genomic Pathology

Dr. Oury is a member of the Division of Molecular Genomic Pathology.

Dr. Oury is co-director of a program designed to transition physician scientist trainees into academic faculty professorships. This combined Residency-Post-doctoral Research Fellowship or combined Residency-PhD program is designed to develop Academic Pathologists to become independent Principal Investigators and to play a leading role in combined research and diagnostic careers.

Clinical Expertise

Molecular Diagnostics

Education & Training
PhD - Duke University, 1993
MD - Duke University, 1994
Research Interests

We are investigating a novel role for the Receptor for Advanced Glycation Endproducts (RAGE) in the pathogenesis of asthma. We have found that RAGE is necessary for initiating innate immune responses that then promote the pathogenesis of asthma. Specifically, we found that RAGE mediates lung specific recruitment of group 2 innate lymphoid cells (ILC2) in response to allergens. We are currently investigating the mechanisms in which RAGE is medicating this process.

Representative Publications

View Dr. Oury's publications on PubMed.

  • Oczypok EA, Milutinovic PS, Alcorn J, Khare A, Crum LT, Manni ML, Epperly MW, Pawluk AM, Ray A, Oury TD. (2015) Pulmonary receptor for advanced glycation endproducts promotes asthma pathogenesis via IL-33 and accumulation of group 2 innate lymphoid cells. J. Allergy Clin. Immun. 136: 747-756.
  • Oczypok EA, Perkins TN, Oury TD. (2017) Alveolar Epithelial Cell-Derived Mediators: Potential Direct Regulators of Large Airway and Vascular Responses. Am. J. Resp. Cell Molec. Biol, 56: 694-699.
  • Oczypok EA, Perkins TN, Oury TD. (2017) All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paed Resp Rev. 23: 40-49.
  • Perkins TN, Oczypok EA, Dutz RE, Oury TD. (2019) RAGE-dependent VCAM-1 expression in the lung endothelium mediates IL-33 induced allergic airway inflammation. Allergy. 74:  89-99.
  • Perkins TN, Oczypok EA, Dutz RE, Donnell ML, Myerburg M, Oury TD, (2019) The Receptor for Advanced glycation endproducts is a critical mediator of type 2 cytokine signaling in the lungs. J. Allergy Clin. Immun. 144:796-808 e12.
  • Perkins TN, Donnell ML, Oury TD, (2021) The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease. Allergy. 76:1350-66.
  • Perkins TN and Oury TD. (2021) The perplexing role of RAGE in pulmonary fibrosis: Causality or casualty? Ther. Adv. Respir. Dis. 15:17534666211016071.
  • Killian KK, Kosanovich JL, Lipp MA Empey KM, Oury TD*, Perkins TN*. (2023) RAGE contributes to allergen driven severe neutrophilic airway inflammation in mice. Front Immunol. 14:1039997.